Now, if these 5-HT2A receptors upregulate in body when blocked, then there is probably a chronic inflammation (of cardiovascular tissues) that doesn't go away even when there is no reason for this.Now when 5-HT2A blockade is withdrawn it seems that this causes chronic inflammation and according to wikipedia: "Chronic inflammation is characterised by the dominating presence of macrophages in the injured tissue.These cells are powerful defensive agents of the body, but the toxins they release (including reactive oxygen species) are injurious to the organism's own tissues as well as invading agents. Consequently, chronic inflammation is almost always accompanied by tissue destruction".
That is, your own immune system attacks against you and destroy's you. Now, that could explain problems with blood circulation (damage) caused by my previous withdrawal attempts, as well as blood in stools and symptoms that are similar to sepsis (or septic shock) etc.
Now, it is likely that 5-HT2A receptors do downregulate very slowly so the withdrawal from 5-HT2A blocking drugs must be super slow and other anti-inflammatory agents must be used to help the withdrawal.Morever, the blood in stools is probably due to the fact that majority of serotonin is produced within intestine/guts and when the medicine is withdrawn serotonin hits 5-HT2A receptors in intestine HARD causing deterrioration and damage in guts/intestine (internal bleeding).This should also clearly explain increased urobilingen levels in urine (microcirculation in guts/intestine gets damaged and blood leaks slowly to guts causing bilurubin to urobilingen production).
People how have withdrawn from Seroquel or Doxepin (or Atarax) or any 5-HT2A antagonist all have the same problems of poor health.One have diarrhea etc., another have heart palpitations, someone else have heartburn and other issues.Probably all are caused by bodywise exagerated inflammatory responses (super potent
Summary:
- chronic inflammation is problem caused by removal of 5-HT2A blockade and this damage can kill you
- measurement and following of leukocytes in urine is a good indication of chronic inflammation caused by removal of 5-HT2A blockade (if there is leukocytes then the withdrawal is too fast, existence of urobilingen in urea means intestine is leaking and we are in danger zone), chronic inflammation is probably also a reason for feeling of "mild flu" when withdrawing from neuroleptics.
- frequent peeing (+ high specific gravity?) can be sign of system trying to get rid of toxins caused by chronic inflammation
- additionally, one can use other anti-inflammatory supplements and antioxidants:
- omega3, curcumin, ginger, aspirin (but increases internal bleeding)
- Zyprexa/Seroquel and other 5-HT2A blocking drugs are killer drugs (when withdrawn).You will probably die to the withdrawal or at least it must be extremely slow (1-2 year long withdrawal from 5-HT2A blockade and superstable doses (so that receptors are kept closed all the time during day)
I believe the problem also has the name: Systemic inflammatory response syndrome.Wikipedia: The clinical condition may lead to renal failure, respiratory distress syndrome, central nervous system dysfunction and possible gastrointestinal bleeding.
Aspirin also reduces inflammation but it also causes internal bleeding so it is not good option once the inflammation has become too significant.
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