pregnancies a*sociated with in vitro fertilisation (IVF).A series of movementsin the egg in the first hours after fertilisation can be used to predict which
embryos have the best chance of survival.progress at this stage used as a predictor of their likely development. However,
around half of all human embryos stop developing before the blastocyst stage at
day five of development.As a result, patients are often implanted with many
embryos at once, which can lead to multiple pregnancies.
In order to improve success rates and reduce the number of multiple pregnancies,
which are potentially risky for the mother and often end in miscarriage, many
IVF clinics delay implantation until embryos have reached the blastocyst stage,
and implant fewer embryos per round of treatment.birth.It is important to be able to quantitate some indication of the health of
embryos at the earliest possible stage in order to minimise the time they have
to spend outside the body of the mother.
There is a non-invasive method of accurately predicting the likelihood that an
embryo will develop not only to the blastocyst stage, but also to birth from as
early as two hours after fertilisation.
Fertilisation initiates a series of pulsating movements in the cytoplasm, the
jelly-like substance which fills the cell.The movements are caused by anand the likelihood that an embryo will develop to the blastocyst stage.This
allowed the group to develop a mathematical model enabling them to predict
successful development beyond this stage all the way to birth. The invention
provides a quantitative method of determining embryo viability which is much
more reliable than current qualitative visual inspection.
In vitro fertilisation is an emotionally and physically demanding experience for
prospective parents, with current success rates of only 30%.Improving success
rates for IVF by choosing the best embryo to implant not only decreases the
risks a*sociated with multiple embryo transfers but also potentially minimises
the number of rounds of IVF that potential mothers must go through in order to
achieve a successful pregnancy. This saves prospective parents both the trauma
and cost of the IVF experiences.
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